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Abstract

In-vitro Antiproliferative Activity Study of 2, 4, 5-Triphenyl-1H-imidazole Derivatives

Various substituted 2, 4, 5-triphenyl-1H-imidazole derivatives were synthesized and evaluated for in vitro antiproliferative activity against human non-small cell lung carcinoma-A549 cell lines by MTT assay method. Compound 2-iodo-6- methoxy-4-(4, 5-diphenyl-1H-imidazol-2-yl) phenol (6f) (IC50: 15 μM) was found to be most promising which inhibits the growth of cancer cells (90.33% of total population).

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Author(s):

Satish A Dake, Kiran R Kharat, Ashok R Yadav, Pravin S Kendrekar and Rajendra P Pawar



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Abstracted/Indexed in

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  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
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