Various substituted 2, 4, 5-triphenyl-1H-imidazole derivatives were synthesized and evaluated for in vitro antiproliferative activity against human non-small cell lung carcinoma-A549 cell lines by MTT assay method. Compound 2-iodo-6- methoxy-4-(4, 5-diphenyl-1H-imidazol-2-yl) phenol (6f) (IC50: 15 μM) was found to be most promising which inhibits the growth of cancer cells (90.33% of total population).
Satish A Dake, Kiran R Kharat, Ashok R Yadav, Pravin S Kendrekar and Rajendra P Pawar
All Published work is licensed under a Creative Commons Attribution 4.0 International License
Copyright © 2018 All rights reserved. iMedPub LTD Last revised : December 11, 2018