Journal of Organic & Inorganic Chemistry

Correlative study of serum hepcidin levels and serum iron reserve parameters in preeclampsia and Hellp syndrome

HELLP syndrome is described as a special group of severe preeclampsia characterized by haemolysis (H), elevated liver enzymes (EL) and low
platelets (PL), whereas preeclampsia is a disease of unknown etiology characterized by hypertension and proteinuria after the 20th week of
gestation. The objective of the study was to evaluate the level of hepcidin in the serum of the patient suffering from HELLP syndrome and
preeclampsia. It was done by competitive sandwich ELISA which assesses the serum level of hepcidin in the forty patients suffering from
preeclampsia and HELLP syndrome (as cases) and forty healthy individuals (as control). The results of our study showed that serum hepcidin
levels were significantly increased among the cases (P =0.00171) in comparison to control (P <0.05) and transferring saturation levels were
significantly decreased (P <0.05) among the cases (P =0.001) in comparison to controls. The decrease in transferrin saturation indicates that
there is low serum iron level among the cases. It was concluded that increased hepcidin level may be the cause of anemia among the cases.

Author(s):

Surendra Pratap Mishra

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