Journal of Organic & Inorganic Chemistry

C-reactive proteins has the potential to inhibit

C-reactive protein (CRP) is an acute phase reactant mainly produced in the liver in response to elevated levels of interleukin-1β (IL-1β) and IL-6.
Its clinical relevance as an indicator of inflammation is outstanding but the biological functions are poorly defined. CRP belongs to the family
of pentraxins and calcium-dependently binds ligands containing a phosphocholine head-group. We demonstrate that CRP isolated from human
bodily fluids is an unconventional agonist of monocytic nicotinic acetylcholine receptors (nAChR) containing subunits α7, α9 and α10. Marginally
pathologic CRP levels (IC50 = 4.9 mg/l) efficiently inhibit ATP-dependent NLRP3 inflammasome activation and IL-1β maturation by human monocytic
cells.

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Author(s):

Garu

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