Journal of Organic & Inorganic Chemistry

Design, synthesis, structure and biological activity of some fused (di)-azine

Nowadays (di)azole and (di)azine heterocyclic systems are one of the most imperative scaffolds in a large variety of natural and pharmacologically active compounds. As far for their medicinal and pharmaceutical applications, these compounds possess a large variety of biological activities such as anthelmintics, antiviral, anticancer, antituberculosis, antimicrobials, antifungal, anti-inflammatory, antihypertensive, cardiotonic, antithrombics, anticoagulants, diuretics, nephrotropic, antidepressant, anxiolytics, anticonvulsant, analgesic, etc., As part of our ongoing research in the field of (di)azole and (di)azine derivatives, we present herein some core results obtained by our group within this area, focused on design, synthesis, and medicinal chemistry applications. Thus, several classes of (di)azole and (di)azine was designed, synthesized, and tested for their biological activity. For the most promising compounds, a complete ADMET studies have been performed with very good results. The molecular docking experiments suggests important clues concerning the mechanism of actions of our (di)azole and (di)azine heterocyclic systems.

Author(s):

Mangalagiu V, Mangalagiu I I, Moldoveanu C, Zbancioc Ghe, Danac R and Antoci V

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