Azaheterocyclic compounds, especially five and six member ring, are reported as highly valuable materials in medicine and pharmacy (drugs, as antiplasmodial and antimalarial, antitubercular, antibacterial, antifungal, anti-inflammatory, anti-HIV, anticancer, analgesic, antidepressant, anxiolytics, anti-Alzheimer’s, antihypertensive, anticoagulants, diuretics, etc.), opto-electronics (fluorescent and electroluminescent materials, semiconductor devices, sensors and biosensors), agriculture (mainly herbicides and grow up factors), etc. This is why, obtaining of such derivatives continues to generate interest from large research teams from academia, industry, agriculture. As part of our on-going research in the field of azaheterocyclic derivatives, we present herein some core results obtained by our group within this field (in the last 10 years), focused on the obtaining of these compounds via Huisgen 3+2 dipolar cycloaddition of cycloimmonium ylides to variously dipolarophiles with double and triple bounds (symmetrically or non-symmetrically). Some briefly considerations about the applications of the obtained compounds in medicine and pharmacy, opto-electronics and agriculture will be presented.
Mangalagiu Ionel, Mangalagiu V, Moldoveanu C, Zbancioc Ghe, Danac R and
Antoci V
Journal of Organic & Inorganic Chemistry received 131 citations as per google scholar report