Journal of Organic & Inorganic Chemistry

Phytochemical Screening and in vitro Anti-inflammatory Activity of Ficus rumphiie extracts

Inflammation is an important nonspecific defense reaction to tissue injuries, such as that caused by a pathogen or wound. Acute inflammation is the rapid response of the body to injury or cell death. There are several plants which possess significant anti-inflammatory properties and Ficus rumphii is one of them. Objective of the present study was to evaluate the anti-inflammatory activity of methanolic extracts of leaves, bark, and root of Ficus rumphii. The in-vitro anti-inflammatory activity was investigated by using the albumin denaturation assay method using aspirin as a reference drug. Preliminary phytochemical analysis revealed the presence of flavonoids, alkaloids, tannins, saponins and carbohydrates in leaves; alkaloids, saponins, flavonoids, amino acid and carbohydrates in root; whereas carbohydrates, amino acid, saponins, flavonoids, and tannins were identified in bark. All the extracts (leaves, bark, and root) were tested at the concentration 50 to 500 µg/mL. Different extract of F. rumphii exhibited a concentration-dependent inhibition of albumin. From the results, it was concluded that phytochemicals (tannins, phenols, and saponins) present in the F. rumphii extract may be responsible for the anti-inflammatory.

Author(s):

Lalit Singh1 , Rohit Bhatia1*, Neeraj Kumar2 , Ravindra K. Rawal3

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